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What is my risk of developing colorectal cancer or other types of cancer? The two genes were previously known to cause Lynch syndrome, an inherited condition that raises the risk of colorectal, ovarian, stomach, and endometrial cancer. In addition, cancers associated with Lynch syndrome are more likely to be diagnosed at a young age.
The finding means that women with Lynch syndrome who have MSH6 or PMS2 variants, but not MLH1 and MSH2 variants, may benefit from increased breast cancer screening, though the researchers caution that the findings need to be replicated in another study. Lynch syndrome is among the most common hereditary cancer syndromes, and estimates suggest as many as 1 in every people may be carriers of an alteration in a gene associated with Lynch syndrome. It is important to discuss these options with your doctor, as each individual is different:.
Lynch syndrome follows an autosomal dominant inheritance pattern, in which a mutation needs to happen in only 1 copy of the gene for the person to have an increased risk of getting that disease. These types of mutations are called acquired. Based on the incidence of cancer in the study population, the researchers calculated that about 31 to 38 percent of women with cancer-causing MSH6 and PMS2 variants will develop breast cancer, compared to around 15 percent of women in the general population.
Colon Cancer Alliance www. The study, in collaboration with GeneDx, a genetic testing company, was published online today in Genetics in Medicine. PGD has been in use for over 2 decades and has been used for several hereditary cancer predisposition syndromes. Is It Good for Society?